Effect of high risk human papillomavirus in esophageal squamous cell carcinoma in Somalian and Turkish cases

  Oncology Pathology

  Yılmaz Baş, Fügen Aker, Aylin Gönültaş, Raşit Akdeniz, Ebru Turgal, Makbule Arar Çıkrıkçıoğlu

Now published in Pathogens and Disease doi: 10.1093/femspd/ftz047

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Abstract

Background/Aims: The incidence of esophageal squamous cell carcinoma (ESCC) varies markedly with race and geographic region. It has been proposed that human papillomavirus (HPV) is involved in the pathogenesis of esophageal cancers, and incidence of esophageal cancers associated with HPV depends on the geographic location of the patient population. This study aimed to investigate whether p53 and p16INK4a expression distributions and high-risk (Hr) human papillomavirus (HPV) types are determinant agents in Turkish and Somalian esophageal squamous cell carcinoma (ESCC) cases. Materials and Methods: In the sections obtained from paraffin-embedded blocks, the results of invasive tumor, peripheral tumor dysplasia and normal mucosa were examined. Samples containing 45 and 47 ESCC, 46 and 42 dysplasia in Somalian (n=52) and Turkish (n=53) cases were included in the study respectively. We examined the presence of 14 types Hr-HPV in ESCC collected from Somali and Turkey by Aptima® Panter System. Results: Hr-HPV types were not detected in Somalian cases. p16INK4a is positive in 5 (11.4%) tumors, 6 (13%) dysplasia. p53 is positive in 28 (62.2%) tumor, 35 (76.1%) dysplasia.HPV16-18/45 are positive only in 1 of Turkish cases. p16INK4a is positive in 5 (10.6%) tumors, 4 (9.5%) dysplasia. p53 is positive in 31 (63.3%) tumor, 24 (57.1%) dysplasia. No reaction was detected in normal mucosa samples in both countries. Conclusion: The present study provides that HPV is not likely to be a major factor in carcinogenesis of ESCC in Somalian and Turkish population.

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